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ACNOC Active Ingredient Xanthone

Mangosteen Peel Extract (Xanthone)

Mangosteen also known as “Queen of fruits” found abundant in Southeast Asia countries like Thailand, Myanmar etc. The peel (pericarp) of mangosteen fruit has been used in traditional medicine in Southeast Asia for centuries to treat infection, wounds, inflammation and diarrhea. Mangosteen provides useful benefits include being high in fiber yet low calories, as well as having a good serving of vitamin C.

Mangosteen not only contains a helpful range of essential vitamins and minerals, but it also contains a natural chemical substance called xanthone which is found only in few tropical plants. Decades of research have found out that there are more than 200 types xanthones in nature and over 40 kinds of xanthone found in Mangosteen peel especially “Alpha-mangostin”.

Chemical Structure of Xanthones


Xanthone Benefits

According to findings from research conducted in 2008 by the Gifu International Institute of Biotechnology in Japan showed that one xanthone from mangosteen peel, in particular, known as alpha-Mangostin, was found to have an agent for cancer prevention in combination with other therapies.  The xanthones have the ability to control cancer cell division and growth, programmed cell death, inflammation, and cancer metastasis.

According to some scientific research has shown that extracts of mangosteen especially alpha- and gamma-mangostin have anti-inflammatory effects and anti-allergy. The extracts proved to be effective and successful inhibitors of the release of histamine and prostaglandin, which are both associated with inflammation in the human body as well as allergies.

According to a study conducted in Thailand found out that Mangosteen peel extract has shown to be an effective home remedy for acne. It also has most important antioxidant activity and suppress the production of pro-inflammatory cytokines that contribute to acne formation

A study of the effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes by a researcher from Mahidol University, Rachathevi, Bangkok, Thailand found out that mangosteen was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines that contribute to acne formation. Alpha-mangostin was also proven to have strong antibacterial activity against Staphylococcus aureus. Mangosteen peel extract has an anti-inflammatory agent which could be useful in the treatment of acne vulgaris.






Mangosteen Xanthones Research: Alpha-Mangostin, http://www.mangosteen-juice-online.com/mangosteen-alpha-mangostin.html

A review of Mangosteen (Garcinia mangostana) Linn., Anthony C. Dweck FLS FRSH FRSC, http://www.dweckdata.co.uk/Published_papers/Garcinia_mangostana.pdf

Garcinia mangostana (Clusiaceae)”. Montoso Gardens. Retrieved 4 December 2012.

Mangosteen Xanthones Research Studies, http://www.mangosteen-juice-online.com/mangosteen-xanthones.html


Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant., Nakatani K1, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y.,  https://www.ncbi.nlm.nih.gov/pubmed/12230104

MANGOSTEEN, MANGOSTEEN FRUIT, XANGO, ALICE SUMMERS DECEMBER 11, 2010, http://www.yummylocal.com/news/whats-mangosteen/